Herpesvirus Hominis (virus of Herpes Simplex).

INTRODUCTION................................................................................. 458 STRUCTURE. ... ................................................................................ 459 BIOCHEMISTRY.............. ... . .... . ............................................... 459 Composition of the Virus 459 Changes Induced by Infection 60 Induction of Enzymes. MECHANISM OF CELL INFECTION.4 Adsorption ................................................................................. 460 Penetration................................................................................... 460 Multiplication .............................................................................. 460 Release of Virus 461 CYTOLOGY. ..................................................................................... 461 Development of Inclusion Body 46 Chromosomal Aberrations 1 Reaction of Cells in Tissue Culture. SEROLOGY. ..................................................................................... 463 Serological Epidemiology 463 Strain Differences Precipitins.4 Hypersensitivity. .. .......................................................................... 464 LATENT INFECTION 65 Reactivation ................................................................................ 465 Persistent Infection in Tissue Culture......................................................... 466 Interferon.................................................................................... 466 RECENT OBSERVATIONS OF CLINICAL INTEREST 467 Unusual Manifestations of Primary Infection in Newborn and Older Infants.467 Newborn.................................................................................. 467 Older infants............................................................................... 467 Mechanisms Whereby the Virus Reaches the Nervous System 467 Antiviral Chemotherapy in Herpetic Infection.46 LITERATURE CITED.468